In Singapore, the advertisement and promotion of medicinal products are controlled under the Medicines Act 1975 and its subsidiary legislation, the Medicines (Medical Advertisements) Regulation 1977. Thus, the application of products which fall under this category must firstly satisfy these regulations.

The Accreditation Committee will review all advertising claims for any product bearing the seal. Claims made in advertising or promotional packaging materials must be accurate in fact and in implication. Only Companies with good standing and the product is not banned by Health Science Authority will be considered for Seal of Approval. All statements relating to the general subject of oral health must be based on current scientific knowledge. All packaging and labeling claims must also be supported by appropriate studies. Advertising of the product must not result in the disparagement of other products.